Alterations in hippocampal serotonergic and INSR function in streptozotocin induced diabetic rats exposed to stress: neuroprotective role of pyridoxine and Aegle marmelose

Table 2 [³H] 5-Hydroxytryptamine binding parameters in the hippocampus of control and experimental rats

Experimental Groups	B_max (fmoles/mg protein)	K_d(nM)
Control	212.5 ± 2.11	3.22 ± 0.54
Diabetic	72.4 ± 3.21 ^a	1.94 ± 0.41 ^a
Diabetic + Insulin	62.8 ± 2.06 ^a	1.40 ± 0.29 ^a
Diabetic + Pyridoxine	148.4 ± 2.33 ^{a, c}	2.60 ± 0.49 ^b
Diabetic + Insulin+ Pyridoxine	196.0 ± 1.43 ^c	3.20 ± 0.17 ^c
Diabetic+ *A. marmelose*	140.1 ± 4.33 ^{a, c}	2.57 ± 1.42 ^b
Diabetic+ *A. marmelose* +Pyridoxine	186.4 ± 2.42 ^c	3.05 ± 1.31 ^c

Values are mean ± S.E.M of 6-8 separate experiments. Each group consists of 6-8 rats.
^a p < 0.001, ^b p < 0.05 when compared to control group; ^c p < 0.001 when compared to diabetic group.

ISSN: 1423-0127