Alterations in hippocampal serotonergic and INSR function in streptozotocin induced diabetic rats exposed to stress: neuroprotective role of pyridoxine and Aegle marmelose

Table 3 [³H] Ketanserin binding parameters in the hippocampus of control and experimental rats

Experimental Groups	B_max (fmoles/mg protein)	K_d(nM)
Control	260.5 ± 0.35	0.68 ± 0.08
Diabetic	176.2 ± 0.19 ^b	0.77 ± 0.17 ^a
Diabetic + Insulin	218.1 ± 0.32 ^d	0.67 ± 0.09 ^c
Diabetic + Pyridoxine	180.6 ± 0.27 ^b	0.70 ± 0.06 ^c
Diabetic + Insulin+ Pyridoxine	244.0 ± 0.26 ^d	0.68 ± 0.11 ^c
Diabetic+ *A. marmelose*	209.3 ± 0.22 ^d	0.68 ± 0.11 ^c
Diabetic+ *A. marmelose* +Pyridoxine	228.2 ± 0.29 ^d	0.67 ± 0.07 ^c

Values are mean ± S.E.M of 6-8 separate experiments. Each group consists of 6-8 rats.
^a p < 0.05, ^b p < 0.001 when compared to control;
^c p < 0.05, ^d p < 0.001 when compared to diabetic group.

ISSN: 1423-0127