Association of phospholipase A2 receptor 1 polymorphisms with idiopathic membranous nephropathy in Chinese patients in Taiwan

Table 1 Genotype and allele frequencies of phospholipase A2 receptor 1 (PLA2R1) single nucleotide polymorphisms (SNPs) in patients with idiopathic membranous nephropathy (IMN) vs healthy controls

SNPs	Controls N (%)	IMN N (%)	p-Value^a	Odds ratio (95% CI)^b
Alleles
rs6757188
C allele	76 (35.8)	83 (32.3)	0.402	1
T allele	136 (64.2)	175 (67.8)		1.178 (0.803-1.729)
Total	212 (100)	258 (100)
rs35771982
C allele	56 (26.4)	41 (15.9)	0.005	1
G allele	156 (73.6)	217 (84.1)		1.900 (1.209-2.987)
Total	212 (100)	258 (100)
Genotypes
rs6757188
C/C	9 (8.5)	15 (11.6)	0.113	1
C/T	58 (54.7)	53 (41.1)		0.548 (0.221-1.357)
T/T	39 (36.8)	61 (47.3)		0.938 (0.374-2.352)
Total	106 (100)	129 (100)
rs35771982
C/C	8 (7.5)	2 (1.6)	0.015	1
C/G	40 (37.7)	37 (28.7)		3.700 (0.738-18.560)
G/G	58 (54.7)	90 (69.7)		6.207 (1.273-30.262)
Total	106 (100)	129 (100)

Abbreviation: CI, confidence interval.
^a Genotype frequencies were determined by χ² test using 2 × 3 contingency tables between patients with IMN and healthy controls. Allele frequencies and restricted genotypes were determined by χ² test using 2 × 2 contingency tables between patients with IMN and healthy controls.
^b Odds ratios and 95% CI per genotype and allele were estimated by applying unconditional logistic regression between patients with IMN and healthy controls.

ISSN: 1423-0127