Figure 2

Cre-mediated recombination in the pancreatic primordium and inner ear in the e10.5 embryo. Whole-mount images of a pdx1-cre^Cre/0; rosa26^LacZ/+ embryo (A & B) and a pdx1-cre^0/0; rosa26^LacZ/+ embryo (C) processed for β-galactosidase activity. β-galactosidase activity was observed in the pancreatic primordium (bottom arrow, left panel) and inner ear formation (top arrow, A; region in higher magnification in B). β-galactosidase activity was not evident in pdx1-cre^0/0; rosa26^LacZ/+ control embryos (C). Scale bars, 1 mm (A and C) and 150 μm (B).