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Figure 3 | Journal of Biomedical Science

Figure 3

From: Role of taurine in the central nervous system

Figure 3

A model depicting the pathway that taurine exerts its function against glutamate-induced apoptosis. Taurine’s neuroprotective functions are due to its role in reducing intracellular free calcium concentration and its antioxidative stress capacity. Taurine can shift the ratio of anti-apoptotic Bcl-2 protein and pro-apoptotic Bax protein towards cell survival. As shown in the diagram taurine inhibits glutamate-induced activation of calcium and the subsequent heterodimerization of Bcl-2 and Bax protein resulting in the apoptosis cascade.

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