Glutamate receptor-mediated taurine release from the hippocampus during oxidative stress

Table 1 Drug effects on tissue swelling and taurine efflux from the hippocampus during oxidative stress.

Drug Treatment	H₂O₂-induced Change in IOS (Percent of Baseline)	H₂O₂-induced Change in Taurine Efflux Rate (Percent of Baseline)
None	0.7 ± 0.6 %	335 ± 178 % *
20 µM DCPIB	3.2 ± 1.0 % *	-11 ± 29 %
10 µM MK-801	4.6 ± 1.9 % *	-55 ± 13 %

All experiments were performed using hippocampal slices prepared with 1 mM taurine to maintain normal taurine contents. Changes in the intrinsic optical signal (IOS) measured in the stratum radiatum of the CA1 region and the taurine efflux rate were determined after 25 min and 8 min of H₂O₂ exposure, respectively. These represent time points which resulted in peak responses observed in control slices with no drug treatment as shown in Figure 1. Values are the mean ± SEM for 3-5 independent measurements. * Indicates values which are significantly different from baseline measurements determined prior to H₂O₂ treatment.

ISSN: 1423-0127