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Figure 5 | Journal of Biomedical Science

Figure 5

From: Neuroprotection by taurine in ethanol-induced apoptosis in the developing cerebellum

Figure 5

Effects of taurine on ethanol-induced apoptosis in the developing cerebellum (A) Number of activated caspase-3 immunoreactive Purkinje cells in the cerebellar lobules of 4-day-old mice in the control (open bars), ethanol-treated (filled bars) and ethanol+taurine-treated (hatched bars) mice. The results are given per mm2 with standard deviations. Number of animals in each group is 5. Ethanol significantly (P<0.01) increased the number of caspase-3 immunoreactive cells in all lobules. There were no significant differences between the ethanol and ethanol+taurine groups. (B) Number of apoptotic Purkinje cells (labeled by TUNEL assay) in the cerebellar lobules of 4-day-old mice in the control (open bars), ethanol-treated (filled bars) and ethanol+taurine-treated (hatched bars) mice. The results are given per mm2 with standard deviations. Number of animals in each group is 5. Ethanol significantly (P<0.01) increased the number of TUNEL-positive Purkinje cells in all lobules. There were no significant differences between the ethanol and ethanol+taurine groups. (C) Number of activated caspase-3-immunoreactive cells in the IGL in the cerebellar lobules of 7-day-old mice in the control (open bars), ethanol-treated (filled bars) and ethanol+taurine-treated (hatched bars) mice. The results are given per mm2 with standard deviations. Number of animals in each group is 5. Ethanol significantly (P<0.01) increased the number of caspase-3 immunoreactive cells in all lobules. The significance of differences between the ethanol and ethanol+taurine groups: *P<0.05.(D) The number of apoptotic cells (labeled by TUNEL assay) in the IGL in the cerebellar lobules of 7-day-old mice in the control (open bars), ethanol-treated (filled bars) and ethanol+taurine-treated (hatched bars) mice. The results are given per mm2 with standard deviation. Number of animals in each group is 5. Ethanol significantly (P<0.01) increased the number of TUNEL-positive cells in all lobules. The significance of differences between the ethanol and ethanol+taurine groups: *P<0.05.

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