Figure 7From: Taurine protection of PC12 cells against endoplasmic reticulum stress induced by oxidative stressProposed mechanism of taurine protection against ER stress induced by oxidative stress in PC12 cells. There are four stages to the process. 1, ROS (H2O2) induces ER stress; 2, this leads to up-regulation of the ER stress marker GRP78 and CHOP/GADD153. 3, CHOP induces apoptosis and up-regulation of BH3-only proapoptotic protein Bim and inhibits the expression of Bcl-2. 4, Bim induces cell apoptosis. Taurine exerts its protection against oxidative stress induced by ROS (H2O2). Taurine suppresses ER stress induced by oxidative stress through down-regulating the expression of GRP78 and CHOP. Furthermore, taurine protects PC12 cells by up-regulation of Bcl-2 and down-regulation of Bim.Back to article page