Figure 13

Photomicrographs of lung sections stained with ApoTag® Plus Peroxidase In Situ Apoptosis Detection kit. The animals received TAU (50 mg/kg/0.5 mL, i.p.) before (A-C) and after (D-F) LPS (0.02 mg). Sections from control (PBS pH 7.4) animals showed no TUNEL positive apoptotic cells (A and D). Sections from animals treated only with LPS (B and E) showed a modest increase in the number of TUNEL positive lung cells relative to samples from control (PBS pH 7.4) animals. A 3-day treatment with TAU, either before (C) or after (F) LPS, reduced the number of TUNEL positive lung cells relative to samples from animals receiving only LPS (magnification of 400x).