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Figure 2 | Journal of Biomedical Science

Figure 2

From: Effect of taurine chloramine on the production of matrix metalloproteinases (MMPs) in adiponectin- or IL-1β-stimulated fibroblast-like synoviocytes

Figure 2

Effect of taurine chloramine on the signaling pathways stimulated by adiponectin. (A) Synovial cells (5 × 105 cells/60-mm dish/2-ml serum-free media) were treated with adiponectin (10 µg/ml). Time courses of the signaling pathways activated during adiponectin stimulation. (B) Synovial cells (5 × 105 cells/60-mm dish/2-ml serum-free media) were treated with TauCl 30 min prior to 30- or 45-min adiponectin (10 µg/ml) or IL-1β (10 ng/ml) stimulation, respectively. TauCl (600 µM) significantly inhibited the IκB-NF-κB signaling pathway by inhibiting the degradation of IκB-α induced by adiponectin, but not that by IL-1β. The data shown are representative of 3 independent experiments, and similar results were obtained from all 3.

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