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Table 5 The effect of gestational taurine supplementation on gene set enrichment analysis of 4 week old mice

From: A maternal low protein diet has pronounced effects on mitochondrial gene expression in offspring liver and skeletal muscle; protective effect of taurine

Category / tissue

Size

ES

NES

FDR

FWER

GO cellular component

     

Liver

     

Mitochondrial ribosome

21

0.58

1.90

0.012

0.038

Microbody

43

0.48

1.92

0.014

0.035

Peroxisome

43

0.48

1.96

0.016

0.026

Organellar ribosome

21

0.58

1.99

0.023

0.018

Ribosomal subunit

19

0.53

1.79

0.032

0.116

Muscle

     

Pore complex

33

0.51

1.50

0.017

0.917

Proteasome complex

22

0.53

1.48

0.020

0.948

Apicolateral plasma membrane

15

-0.60

-1.78

0.043

0.102

Voltage gated potassium channel complex

22

-0.56

-1.89

0.052

0.043

Extracellular region

236

-0.32

-1.68

0.060

0.218

KEGG

     

Liver

     

Biosynthesis of steroids

22

0.81

2.79

0.000

0.000

Hematopoietic cell lineage

45

-0.62

-1.86

0.007

0.006

Fatty acid metabolism

37

0.48

1.81

0.026

0.057

Butanoate metabolism

37

0.45

1.76

0.029

0.083

Glycerolipid metabolism

39

0.46

1.81

0.038

0.056

Muscle

     

Metabolism of xenobiotics by cytochrome P450

23

-0.64

-2.24

0.001

0.001

Complement and coagulation cascades

34

-0.52

-1.91

0.007

0.024

Ribosome

54

-0.46

-1.93

0.009

0.021

Neuroactive ligand receptor interaction

86

-0.41

-1.83

0.010

0.046

Alzheimers disease

23

-0.51

-1.76

0.019

0.100

  1. Gene set enrichment analysis (GSEA) was performed in order to detect differences between liver and skeletal muscle of 4 week old mice subjected to taurine supplementation during gestation as described in materials and methods. The top 5 most significant genesets (based on FDR) is shown. Size) total number of genes in analysis from the geneset. ES) Enrichment score, reflects the degree to which a gene set is overrepresented. NES) Normalized enrichment score, is an ES score that is comparable between genesets. A positive value for ES and NES indicates an upregulation of said geneset by taurine, likewise a negative value indicates a downregulation of the geneset in question. FDR) False discovery rate. FWER) Family-wise error rate.