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Table 5 The effect of gestational taurine supplementation on gene set enrichment analysis of 4 week old mice

From: A maternal low protein diet has pronounced effects on mitochondrial gene expression in offspring liver and skeletal muscle; protective effect of taurine

Category / tissue Size ES NES FDR FWER
GO cellular component      
Liver      
Mitochondrial ribosome 21 0.58 1.90 0.012 0.038
Microbody 43 0.48 1.92 0.014 0.035
Peroxisome 43 0.48 1.96 0.016 0.026
Organellar ribosome 21 0.58 1.99 0.023 0.018
Ribosomal subunit 19 0.53 1.79 0.032 0.116
Muscle      
Pore complex 33 0.51 1.50 0.017 0.917
Proteasome complex 22 0.53 1.48 0.020 0.948
Apicolateral plasma membrane 15 -0.60 -1.78 0.043 0.102
Voltage gated potassium channel complex 22 -0.56 -1.89 0.052 0.043
Extracellular region 236 -0.32 -1.68 0.060 0.218
KEGG      
Liver      
Biosynthesis of steroids 22 0.81 2.79 0.000 0.000
Hematopoietic cell lineage 45 -0.62 -1.86 0.007 0.006
Fatty acid metabolism 37 0.48 1.81 0.026 0.057
Butanoate metabolism 37 0.45 1.76 0.029 0.083
Glycerolipid metabolism 39 0.46 1.81 0.038 0.056
Muscle      
Metabolism of xenobiotics by cytochrome P450 23 -0.64 -2.24 0.001 0.001
Complement and coagulation cascades 34 -0.52 -1.91 0.007 0.024
Ribosome 54 -0.46 -1.93 0.009 0.021
Neuroactive ligand receptor interaction 86 -0.41 -1.83 0.010 0.046
Alzheimers disease 23 -0.51 -1.76 0.019 0.100
  1. Gene set enrichment analysis (GSEA) was performed in order to detect differences between liver and skeletal muscle of 4 week old mice subjected to taurine supplementation during gestation as described in materials and methods. The top 5 most significant genesets (based on FDR) is shown. Size) total number of genes in analysis from the geneset. ES) Enrichment score, reflects the degree to which a gene set is overrepresented. NES) Normalized enrichment score, is an ES score that is comparable between genesets. A positive value for ES and NES indicates an upregulation of said geneset by taurine, likewise a negative value indicates a downregulation of the geneset in question. FDR) False discovery rate. FWER) Family-wise error rate.