TY - JOUR AU - El Idrissi, Abdeslem AU - Yan, Xin AU - Sidime, Francoise AU - L’Amoreaux, William PY - 2010 DA - 2010/08/24 TI - Neuro-endocrine basis for altered plasma glucose homeostasis in the Fragile X mouse JO - Journal of Biomedical Science SP - S8 VL - 17 IS - 1 AB - The fragile X mouse model shows an increase in seizure susceptibility, indicating an involvement of the GABAergic system via an alteration in cellular excitability. In the brain, we have previously described a reduction in GABAA receptor expression as a likely basis for this susceptibility. In the brains of fragile X mice, this reduction in receptor expression culminates with a concomitant increase in the expression of glutamic acid decarboxylase (GAD), the enzyme responsible for GABA synthesis. Further, voltage-sensitive calcium channel expression is reduced in the pancreas of the fragile X mouse. Since there are considerable similarities in the GABAergic system in the brain and pancreas, we evaluated the protective role of taurine in pancreatic islet development in both wild type (WT) and fragile X mice (KO). SN - 1423-0127 UR - https://doi.org/10.1186/1423-0127-17-S1-S8 DO - 10.1186/1423-0127-17-S1-S8 ID - El Idrissi2010 ER -