Reduction in antioxidant enzyme expression and sustained inflammation enhance tissue damage in the subacute phase of spinal cord contusive injury

Wang, Chih-Yen; Chen, Jen-Kun; Wu, Yi-Ting; Tsai, May-Jywan; Shyue, Song-Kun; Yang, Chung-Shi; Tzeng, Shun-Fen

doi:10.1186/1423-0127-18-13

Journal of Biomedical Science

Table 3 List of proteins that showed a decreased (down) or an increased (up) trend (p > 0.05) in the lesion center of the injured spinal cord from the subacute (day 14) SCI group when compared to that detected in the acute (day 1) SCI group.

From: Reduction in antioxidant enzyme expression and sustained inflammation enhance tissue damage in the subacute phase of spinal cord contusive injury

Spot no.	Function	Protein name	Protein ID	Expression (14d/1d)	14d_mean (SEM)	1d_mean (SEM)	p value	Mw/pI	Score
119	actin filament binding	Fascin	FSCN1	down	0.053 (0.022)	0.106 (0.046)	0.406	54474/6.44	184
6,7	anti-apoptosis	60 kDa heat shock protein, mitochondrial	CH60	down	0.123 (0.050)	0.744 (0.340)	0.052	61088/5.91	96
11,12	isomerase	Protein disulfide-isomerase A3, p58	PDIA3	down	0.618 (0.188)	1.386 (0.955)	0.344	57044/5.88	80
13,14	metabolism	D-3-phosphoglycerate dehydrogenase	SERA	down	0.096 (0.081)	0.231 (0.087)	0.355	56457/6.28	90
38	metabolism	Acetyl-CoA acetyltransferase, cytosolic	THIC	down	0.052 (0.009)	0.189 (0.112)	0.272	41538/6.86	60
44,45	metabolism	Fructose-bisphosphate aldolase A	ALDOA	down	1.256 (0.239)	1.905 (0.570)	0.292	39783/8.31	125
46	metabolism	L-lactate dehydrogenase B chain	LDHB	down	0.396 (0.072)	1.092 (0.613)	0.283	36874/5.70	71
99	metabolism	Malate dehydrogenase, cytoplasmic	MDHC	down	0.240 (0.087)	0.648 (0.238)	0.121	36117/8.93	217
100, 101	metabolism	Carbonic anhydrase 2	CAH2	down	0.053 (0.025)	0.484 (0.228)	0.071	29096/6.89	76
109	metabolism	Glycine amidinotransferase, mitochondrial	GATM	down	0.032 (0.011)	0.052 (0.016)	0.416	48724/7.17	146
113~ 115	metabolism	Aconitate hydratase, mitochondrial	ACON	down	0.164 (0.058)	0.712 (0.323)	0.102	86121/7.87	183
39	metabolism	Creatine kinase M-type	KCRM	down	0.066 (0.020)	0.101 (0.032)	0.391	43246/6.58	63
30,31	metabolism	Phosphoglycerate kinase 1	PGK1	down	0.452 (0.123)	0.803 (0.468)	0.446	44909/8.02	116
9,10	microtubule	Tubulin alpha-1B chain	TBA1B	down	1.111 (0.488)	1.941 (0.876)	0.370	50120/4.94	86
89	microtubule	Tubulin alpha-1A chain	TBA1A	down	0.146 (0.039)	0.279 (0.062)	0.102	50788/4.94	135
88,90, 91	neurogenesis	Dihydropyrimidinase-related protein 2	DPYL2	down	0.176 (0.088)	0.313 (0.116)	0.366	62638/5.95	105
92~94	neuron differentiation	Dihydropyrimidinase-related protein 5	DPYL5	down	0.061 (0.046)	0.319 (0.189)	0.132	61501/6.60	117
105	oxidoreduction	Dihydrolipoyl dehydrogenase, mitochondrial	DLDH	down	0.151 (0.069)	0.376 (0.165)	0.214	54574/7.96	84
95	oxidoreduction	Catalase	CATA	down	0.028 (0.027)	0.056 (0.013)	0.364	59719/7.07	187
82,83	protease inhibitor	Serine protease inhibitor A3K	SPA3K	down	0.299 (0.078)	0.866 (0.289)	0.073	46532/5.31	113
15	protein assembly	Stress-induced-phosphoprotein 1, Hsc70/Hsp90-organizing protein	STIP1	down	0.035 (0.020)	0.172 (0.139)	0.288	63158/6.40	65
17	proteolysis	Cytosol aminopeptidase	AMPL	down	0.122 (0.040)	0.188 (0.064)	0.400	56514/6.77	62
120	stress response	Heat shock cognate 71 kDa protein	HSP7C	down	0.391 (0.257)	0.865 (0.332)	0.288	71055/5.37	123
119	actin filament binding	Fascin	FSCN1	down	0.053 (0.022)	0.106 (0.046)	0.406	54474/6.44	184
63	anti-apoptosis	Lactoylglutathione lyase	LGUL	up	0.488 (0.078)	0.231 (0.090)	0.074	20977/5.12	67
62	cell proliferation	Translationally-controlled tumor protein	TCTP	up	0.181 (0.051)	0.058 (0.057)	0.216	19564/4.76	128
8	chaperone	Protein disulfide-isomerase	PDIA1	up	0.897 (0.253)	0.263 (0.099)	0.097	57315/4.82	197
67	chaperone	Protein DJ-1	PARK7	up	0.260 (0.087)	0.113 (0.034)	0.198	19961/6.32	68
124	chaperone	T-complex protein 1 subunit beta	TCPB	up	0.078 (0.015)	0.031 (0.030)	0.190	57422/6.01	76
21	metabolism	Elongation factor 1-alpha 1	EF1A1	up	0.631 (0.273)	0.160 (0.055)	0.142	50424/9.10	77
29	metabolism	Isocitrate dehydrogenase [NADP]	IDHC	up	0.113 (0.111)	0.056 (0.044)	0.679	47047/6.53	108
50	metabolism	L-lactate dehydrogenase A chain	LDHA	up	0.209 (0.045)	0.080 (0.028)	0.058	36712/8.45	64
53	metabolism	Dimethylarginine dimethylaminohydrolase 2	DDAH2	up	0.118 (0.044)	0.015 (0.014)	0.158	30011/5.66	116
73,75	oxidoreduction	Peroxiredoxin-1	PRDX1	up	0.684 (0.378)	0.076 (0.036)	0.158	22323/8.27	91
65	oxidoreduction	Peroxiredoxin-6	PRDX6	up	0.199 (0.104)	0.074 (0.023)	0.359	24860/5.64	74
79	protein assembly	78 kDa glucose-regulated protein	GRP78	up	0.323 (0.116)	0.136 (0.045)	0.245	72473/5.07	285
51	proteolysis	Cathepsin B	CATB	up	0.245 (0.081)	0.159 (0,158)	0.619	38358/5.36	72
106, 107	proteolysis	Cathepsin D	CATD	up	0.840 (0.373)	0.036 (0.026)	0.075	45165/6.66	132
64	signal transduction	Phosphatidylethanolamine-binding protein 1	PEBP1	up	1.539 (0.440)	0.910 (0.214)	0.277	20902/5.48	82
72	signal transduction	GTP-binding nuclear protein Ran	RAN	up	0.184 (0.090)	0.116 (0.055)	0.606	46532/5.31	113
57	stress response	Endoplasmic reticulum protein ERp29	ERP29	up	0.118 (0.091)	0.029 (0.029)	0.513	28614/6.23	63
56	ubiquitin-dependent protein catabolism	Proteasome subunit alpha type-1	PSA1	up	0.177 (0.038)	0.091 (0.027)	0.162	29784/6.15	64

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ISSN: 1423-0127

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