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Figure 9 | Journal of Biomedical Science

Figure 9

From: Regulation of cardiac microRNAs by serum response factor

Figure 9

The mir-21 microRNA represses cardiac actin expression, but SRF and its cofactors activate cardiac actin expression. The mir-21 microRNA repressed cardiac actin gene expression compared with control (P < 0.05*, n = 3). Transfection of several other genes up-regulated the cardiac actin gene compared with mir-21 alone: p49/Strap (p49), Zipzap (Zip), SRF-Δ3 isoform (Δ3), SRF, Nkx2.5, GATA-4, respectively (P < 0.05*, n = 3).

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