Effect of various inhibitors on the increase in [Ca2+]
induced by 10 mM [Ca2+]
or 300 μM GdCl
(CaSR agonists) in PASMCs. A.10 mM [Ca2+]o caused an increased FI of [Ca2+]i ( P < 0.01 versus control ), and the pretreatment with 10 μM thapsigargin, 10 mM caffeine, 10 μM U73122, or 75 μM 2-APB either decreased or abolish increase the FI of [Ca2+]i induced by 10 mM [Ca2+]o, but 10 μM U73343 had no significant effect on it (n = 20). B. The changes in patterns of [Ca2+]i induced by 300 μM GdCl3 and various inhibitors were the same as in A.