Figure 4

The effects of different treatments on the vascular tension of the pulmonary arteries with increased [Ca²⁺] ₀ . [Ca²⁺]_o from 5 to 12.5 mM caused a vasoconstriction of the pulmonary arterys (P < 0.01 versus vehicle, n = 8). In the NiCl₂ + CdCl₂ pretreated groups, the vasoconstriction of the pulmonary arterys was attenuated, but it was higher than in the vehicle (P < 0.01 versus CaCl₂ groups). In the NPS2390 pretreated groups, the vasoconstriction of the pulmonary arterys was also attenuated, but it was higher than in the vehicle (P < 0.01 versus CaCl₂ groups). In the NPS2390 + NiCl₂ + CdCl₂ treated groups, the vasoconstriction of the pulmonary artery was significantly attenuated.