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Figure 4 | Journal of Biomedical Science

Figure 4

From: Cellular stress-induced up-regulation of FMRP promotes cell survival by modulating PI3K-Akt phosphorylation cascades

Figure 4

Inhibition of Akt signaling pathway in FMRP knock-downed cells. Cells were transduced with shRNA virus as mentioned above. After adaptation, cells were treated with ETO (20 μM, 3 hr). Then phosphorylated Akt signaling pathways were analyzed using Western blot assays. ETO-induced PI3K (A) and Akt (B) phosphorylation and Bcl-xL (C) expression were decreased compared with control in FMRP knock-downed HeLa cells. Graphs represent the densitometric quantification of the band intensity. * significantly different as compared with control, # significantly different as compared with control virus (CV) group (p < 0.01, n = 4). Con: control, CV: sh non targeted control virus and FV: shFmr1 virus.

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Journal of Biomedical Science

ISSN: 1423-0127