Figure 1

Inhibitory effects of ketamine, D-APV and ifenprodil on NMDA-induced potentials in hippocampal slices of mice. A representative recordings show the field potentials induced by NMDA (100 μM) and co-application of NMDA with ketamine (a, 10 μM) or D-APV (c, 50 μM). (b, d, e) Histograms represent the average amplitude of field potentials during superfusion of hippocampal slices with NMDA and co-application of NMDA together with ketamine, D-APV, or ifenprodil at the concentrations of 1-50 μM. All values are expressed as the mean ± S.E.M (n = 6). Data were analyzed by one-way ANOVA followed by a Student-Newman-Keuls post-hoc test. *P < 0.05 as compared with the baseline. ^#P < 0.05 as compared with the NMDA groups and treated with NMDA alone.