Figure 2

Effects of mGluR5 modulators on NMDA-induced field potentials and the NMDA receptor blockade by ketamine, D-APV, or ifenprodil in hippocampal slices. (a) A representative recording showing co-application of CHPG (50 μM) enhanced NMDA (100 μM)-induced potentials and prevented ketamine (10 μM)-evoked suppression on NMDA receptors. Summary data showing the average amplitude of field potentials induced by NMDA with and without ketamine (b, 10 μM), D-APV (c, 50 μM), or ifenprodil (d, 5 μM) as well as in the co-application of mGluR5 modulators, DFB (10 μM), CHPG (50 μM), or CDPPB (10 μM). All values are expressed as the mean ± S.E.M. (n = 5-7). Data were analyzed by one-way ANOVA followed by a Student-Newman-Keuls post-hoc test. ^#p < 0.05 as compared with the NMDA groups. *p < 0.05 as compared with the NMDA plus ketamine or D-APV groups.