Figure 2From: Protein kinases modulate store-operated channels in pulmonary artery smooth muscle cellsPKG inhibition by KT5823 augments SOC whole cell currents. Using whole cell patch clamp electrophysiology, PASMCs were voltage clamped and then periodically exposed to a step protocol (-80 mV to +20 mV, 20 mV increments, 300 ms duration) in the absence and presence of 3 μM KT5823 ± 10 μM SKF-96365 (SKF) or 0.1 mM Ni2+. A representative trace and summary data can be found in A &B, respectively. Data are means ± SE, n = 6. * and # denote significant difference from control and KT5832, respectively.Back to article page