PKG inhibition by KT5823 augments SOC whole cell currents. Using whole cell patch clamp electrophysiology, PASMCs were voltage clamped and then periodically exposed to a step protocol (-80 mV to +20 mV, 20 mV increments, 300 ms duration) in the absence and presence of 3 μM KT5823 ± 10 μM SKF-96365 (SKF) or 0.1 mM Ni2+. A representative trace and summary data can be found in A &B, respectively. Data are means ± SE, n = 6. * and # denote significant difference from control and KT5832, respectively.