Figure 6

I+G mice showed increased monocyte/neutrophil counts with elevation of inflammatory profiles which can be attenuated by simvastatin therapy, but not by tirofiban treatment. (A) Expression of CD11b on blood serum collected from control (C), I+G, and I+G with simvastatin treatment (I+G+St) groups respectively. Blood was labeled with PE-conjugated rat anti-mouse CD11b antibody and FITC-conjugated Ly-6G monoclonal antibody separately, then flow cytommetry was performed on a BD FACScan flow cytometry system. Experiments were performed twice with similar results (n = 3 mice in each group); * p < 0.05, ** p < 0.001, respectively. (B) The mouse serum was harvested and the protein levels of MCP-1 and ICAM-1 were determined by ELISA; ** p < 0.001 vs control group; ^†P < 0.05, ^††P < 0.01 vs I+G group, respectively. (C) The mouse serum was collected from control, I+G, and I+G with tirofiban treatment groups respectively.