Granulocyte-CSF induced inflammation-associated cardiac thrombosis in iron loading mouse heart and can be attenuated by statin therapy

Table 1 Echocardiographic results at the end of 2^nd and 4^th week in I+G and other experimental groups

	HR (bpm)	LVPWs (cm)	LVIDSs (cm)	IVSs (cm)	LVPWd (cm)	LVIDd (cm)	IVSd (cm)	EF (%)	FS (%)	E/A ratio
2wks
C	360.5 ± 33	0.08 ± 0.01	0.22 ± 0.03	0.11 ± 0.01	0.07 ± 0.01	0.35 ± 0.03	0.06 ± 0.01	75.75 ± 5.1	37.90 ± 4.4	1.83 ± 0.22
G	333.0 ± 40	0.10 ± 0.02	0.25 ± 0.04	0.12 ± 0.01	0.07 ± 0.01	0.37 ± 0.02	0.07 ± 0.01	70.40 ± 11	33.53 ± 8.0	1.85 ± 0.23
I	372.2 ± 45	0.08 ± 0.02	0.24 ± 0.02	0.11 ± 0.02	0.05 ± 0.01	0.36 ± 0.04	0.06 ± 0.01	69.88 ± 3.6	33.50 ± 1.5	2.07 ± 0.59
I+G	362.9 ± 12	0.08 ± 0.01	0.24 ± 0.02	0.12 ± 0.02	0.06 ± 0.01	0.36 ± 0.02	0.06 ± 0.01	71.78 ± 5.6	35.23 ± 2.1	1.94 ± 0.39
4wks
C	333.5 ± 78	0.10 ± 0.02	0.22 ± 0.04	0.11 ± 0.02	0.07 ± 0.01	0.35 ± 0.03	0.06 ± 0.01	73.68 ± 6.5	36.39 ± 5.4	1.89 ± 0.17
G	348.2 ± 32	0.08 ± 0.02	0.25 ± 0.02	0.10 ± 0.01	0.06 ± 0.01	0.36 ± 0.02	0.06 ± 0.01	65.58 ± 4.3	30.78 ± 2.6	1.85 ± 0.23
I	325.8 ± 95	0.08 ± 0.04	0.23 ± 0.06	0.10 ± 0.02	0.06 ± 0.03	0.34 ± 0.04	0.06 ± 0.02	68.50 ± 12.7	32.94 ± 11.3	1.97 ± 0.14
I+G	315.9 ± 58	0.09 ± 0.01	0.28 ± 0.02*	0.12 ± 0.01	0.06 ± 0.01	0.38 ± 0.02*	0.08 ± 0.01^†	58.65 ± 4.5^†	26.26 ± 2.8^†	1.85 ± 0.22^†

IVSd, inter-ventricular septum thickness at diastole; LVIDd, left ventricular internal diameter at diastole; LVPWd, left ventricular posterior wall thickness at diastole; IVSs, inter-ventricular septum thickness at systole; LVIDs, left ventricular internal diameter at systole; LVPWs, left ventricular posterior wall thickness at systole; FS, fractional shortening of left ventricle; EF, ejection fraction of left ventricle; E/A, E wave/A wave ratio at left ventricular diastolic phase;*p < 0.05, ^†p < 0.01 vs control, n = 12 in each group.

ISSN: 1423-0127