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Table 2 Total GABA receptor binding parameters in the cerebellum and brain stem of control and experimental neonatal rats.

From: Decreased GABAB receptor function in the cerebellum and brain stem of hypoxic neonatal rats: Role of glucose, oxygen and epinephrine resuscitation

Experimental groups Cerebellum Brain stem
B max (fmoles/mg protein) K d (nM) B max (fmoles/mg protein) K d (nM)
   Control 71.50 ± 2.41 11.11 ± 0.95 153.36 ± 3.7 4.77 ± 0.44
   Hx 50.01 ± 1.80 a 14.82 ± 0.82 a 116.68 ± 2.8 a 3.77 ± 0.22 a
   Hx + G 62.18 ± 1.50 b 9.85 ± 0.36 b 173.36 ± 2.5 b 6.78 ± 0.35 a, b
   Hx + G + O 66.33 ± 2.00 b 12.54 ± 0.42 160.84 ± 3.4 b 5.01 ± 0.26 a, b
   Hx + O 55.34 ± 2.50 a 15.72 ± 0.54 a 136.68 ± 2.3 a, b 4.73 ± 0.29 b
   Hx + E 44.02 ± 3.20 a 10.46 ± 0.10 b 122.08 ± 2.6 a 3.30 ± 0.14 a
Hx + G + E + O 45.50 ± 2.50 a 7.46 ± 0.11a, b 125.84 ± 4.5 a 4.10 ± 0.22 b
  1. Values are Mean ± S.E.M of 4-6 separate experiments. Each group consist 6-8 neonatal rats.
  2. a p < 0.001 when compared with control
  3. b p < 0.001 when compared with hypoxic group.
  4. Hypoxic rats- Hx, Hypoxic rats glucose treated - Hx+G, Hypoxic rats oxygen treated - Hx+O, Hypoxic rats glucose and oxygen treated - Hx+G+O, Hypoxic rats epinephrine treated - Hx + E, Hypoxic rats glucose, epinephrine and oxygen treated - Hx+G+E+O