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Table 2 Total GABA receptor binding parameters in the cerebellum and brain stem of control and experimental neonatal rats.

From: Decreased GABAB receptor function in the cerebellum and brain stem of hypoxic neonatal rats: Role of glucose, oxygen and epinephrine resuscitation

Experimental groups

Cerebellum

Brain stem

B max (fmoles/mg protein)

K d (nM)

B max (fmoles/mg protein)

K d (nM)

   Control

71.50 ± 2.41

11.11 ± 0.95

153.36 ± 3.7

4.77 ± 0.44

   Hx

50.01 ± 1.80 a

14.82 ± 0.82 a

116.68 ± 2.8 a

3.77 ± 0.22 a

   Hx + G

62.18 ± 1.50 b

9.85 ± 0.36 b

173.36 ± 2.5 b

6.78 ± 0.35 a, b

   Hx + G + O

66.33 ± 2.00 b

12.54 ± 0.42

160.84 ± 3.4 b

5.01 ± 0.26 a, b

   Hx + O

55.34 ± 2.50 a

15.72 ± 0.54 a

136.68 ± 2.3 a, b

4.73 ± 0.29 b

   Hx + E

44.02 ± 3.20 a

10.46 ± 0.10 b

122.08 ± 2.6 a

3.30 ± 0.14 a

Hx + G + E + O

45.50 ± 2.50 a

7.46 ± 0.11a, b

125.84 ± 4.5 a

4.10 ± 0.22 b

  1. Values are Mean ± S.E.M of 4-6 separate experiments. Each group consist 6-8 neonatal rats.
  2. a p < 0.001 when compared with control
  3. b p < 0.001 when compared with hypoxic group.
  4. Hypoxic rats- Hx, Hypoxic rats glucose treated - Hx+G, Hypoxic rats oxygen treated - Hx+O, Hypoxic rats glucose and oxygen treated - Hx+G+O, Hypoxic rats epinephrine treated - Hx + E, Hypoxic rats glucose, epinephrine and oxygen treated - Hx+G+E+O