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Table 3 GABAB receptor binding parameters in the cerebellum and brain stem of control and experimental neonatal rats.

From: Decreased GABAB receptor function in the cerebellum and brain stem of hypoxic neonatal rats: Role of glucose, oxygen and epinephrine resuscitation

Experimental groups Cerebellum Brain stem
B max (fmoles/mg protein) K d (nM) B max (fmoles/mg protein) K d (nM)
   Control 71.50 ± 2.41 11.11 ± 0.95 74.27 ± 1.20 13.31 ± 1.00
   Hx 50.01 ± 1.80 a 14.82 ± 0.82 a 51.84 ± 1.50 a 14.44 ± 0.99 b
   Hx + G 62.18 ± 1.50 b 9.85 ± 0.36 b 69.41 ± 1.40 b 20.47 ± 0.99 a
   Hx + G + O 66.33 ± 2.00 b 12.54 ± 0.42 70.47 ± 1.10 c 26.10 ± 1.20 a
   Hx + O 55.34 ± 2.50 a 15.72 ± 0.54 a 49.10 ± 1.10 a 16.36 ± 1.50 a
   Hx + E 44.02 ± 3.20 a 10.46 ± 0.10 b 43.59 ± 1.5 a 14.53 ± 0.99 b
Hx + G + E + O 45.50 ± 2.50 a 7.46 ± 0.11a, b 53.95 ± 1.5 a 13.90 ± 0.99 b
  1. Values are Mean ± S.E.M of 4-6 separate experiments. Each group consist 6-8 neonatal rats.
  2. a p < 0.001, b p < 0.05 when compared with control
  3. c p < 0.001 when compared with hypoxic group.
  4. Hypoxic rats- Hx, Hypoxic rats glucose treated - Hx+G, Hypoxic rats oxygen treated - Hx+O, Hypoxic rats glucose and oxygen treated - Hx+G+O, Hypoxic rats epinephrine treated - Hx + E, Hypoxic rats glucose, epinephrine and oxygen treated - Hx+G+E+O