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Table 3 GABAB receptor binding parameters in the cerebellum and brain stem of control and experimental neonatal rats.

From: Decreased GABAB receptor function in the cerebellum and brain stem of hypoxic neonatal rats: Role of glucose, oxygen and epinephrine resuscitation

Experimental groups

Cerebellum

Brain stem

B max (fmoles/mg protein)

K d (nM)

B max (fmoles/mg protein)

K d (nM)

   Control

71.50 ± 2.41

11.11 ± 0.95

74.27 ± 1.20

13.31 ± 1.00

   Hx

50.01 ± 1.80 a

14.82 ± 0.82 a

51.84 ± 1.50 a

14.44 ± 0.99 b

   Hx + G

62.18 ± 1.50 b

9.85 ± 0.36 b

69.41 ± 1.40 b

20.47 ± 0.99 a

   Hx + G + O

66.33 ± 2.00 b

12.54 ± 0.42

70.47 ± 1.10 c

26.10 ± 1.20 a

   Hx + O

55.34 ± 2.50 a

15.72 ± 0.54 a

49.10 ± 1.10 a

16.36 ± 1.50 a

   Hx + E

44.02 ± 3.20 a

10.46 ± 0.10 b

43.59 ± 1.5 a

14.53 ± 0.99 b

Hx + G + E + O

45.50 ± 2.50 a

7.46 ± 0.11a, b

53.95 ± 1.5 a

13.90 ± 0.99 b

  1. Values are Mean ± S.E.M of 4-6 separate experiments. Each group consist 6-8 neonatal rats.
  2. a p < 0.001, b p < 0.05 when compared with control
  3. c p < 0.001 when compared with hypoxic group.
  4. Hypoxic rats- Hx, Hypoxic rats glucose treated - Hx+G, Hypoxic rats oxygen treated - Hx+O, Hypoxic rats glucose and oxygen treated - Hx+G+O, Hypoxic rats epinephrine treated - Hx + E, Hypoxic rats glucose, epinephrine and oxygen treated - Hx+G+E+O
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Journal of Biomedical Science

ISSN: 1423-0127