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Figure 1 | Journal of Biomedical Science

Figure 1

From: Protein kinase A-dependent Neuronal Nitric Oxide Synthase Activation Mediates the Enhancement of Baroreflex Response by Adrenomedullin in the Nucleus Tractus Solitarii of Rats

Figure 1

Involvement of nNOS-dependent mechanism in the effect of ADM on BRR response. A: Temporal changes in BRR response of the rat that received bilateral microinjections into NTS of aCSF, L-NAME (25 pmol), ADM (0.2 pmol) or ADM plus L-NAME. B: Temporal changes in BRR response of the rat that received bilateral microinjections into NTS of aCSF, NPLA (250 pmol), ADM (0.2 pmol) or ADM plus NPLA. C: Temporal changes in BRR response of the rat that received bilateral microinjections into NTS of aCSF, SMT (250 pmol), ADM (0.2 pmol) or ADM plus SMT. D: Temporal changes in BRR response of the rat that received bilateral microinjections into NTS of aCSF, L-NIO (100 pmol), ADM (0.2 pmol) or ADM plus L-NIO. Data are presented as means ± SEM, n = 6 to 8 animals per group. * p < 0.05 compared with control; † p < 0.05 compared with the ADM group at 10, 30 or 60 mins.

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