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Figure 4 | Journal of Biomedical Science

Figure 4

From: Protein kinase A-dependent Neuronal Nitric Oxide Synthase Activation Mediates the Enhancement of Baroreflex Response by Adrenomedullin in the Nucleus Tractus Solitarii of Rats

Figure 4

ADM-induced PKA-dependent phosphorylation of nNOS. Representative Western blotting gels showing changes in phosphorylation at Ser1416 of nNOS (p-nNOSS1416) at 10 min after intra-NTS microinjection of aCSF (control), PKA inhibitor Rp-8-Br-cAMP (PKAi; 1 nmol), ADM (0.2 pmol), or ADM plus PKAi. B: Quantified data showing changes in the protein level of phospho-nNOS in NTS of the rat that received bilateral microinjections into NTS of aCSF, PKAi (1 nmol), ADM (0.2 pmol), or ADM plus PKAi. Data are presented as means ± SEM. *p < 0.05 compared with control; #p < 0.05 compared with the ADM group.

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