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Figure 5 | Journal of Biomedical Science

Figure 5

From: Protein kinase A-dependent Neuronal Nitric Oxide Synthase Activation Mediates the Enhancement of Baroreflex Response by Adrenomedullin in the Nucleus Tractus Solitarii of Rats

Figure 5

Involvement of PKA-dependent NOS activation in the effect of ADM on BRR response. A: Temporal changes in BRR response of the rat that received bilateral microinjections into NTS of ADM (0.2 pmol), 8-Br-cAMP (400 pmol), or SIN-1 (1 nmol). B: Temporal changes in BRR response of the rat that received bilateral microinjections into NTS of aCSF, ADM (0.2 pmol), 8-Br-cAMP (400 pmol) plus L-NAME (25 pmol), or SIN-1 (1 nmol) plus Rp-8-Br-cAMP (1 nmol). C: Temporal changes in BRR response of the rat that received bilateral microinjections into NTS of aCSF, ADM (0.2 pmol), GSNO (0.5 nmol), or GSNO plus Rp-8-Br-cAMP (1 nmol). Data are presented as means ± SEM, n = 6 to 8 animals per group. * p < 0.05 compared with control at 10, 30 or 60 mins.

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