Figure 1

Season of birth patterns, for mean number of TCRVβ peaks in the 24 TCRVβ types. The mean numbers of peaks per TCRVβ type (a measure of T cell clonal diversity) which is calculated as the average of the sum of the peaks in each of the 24 TCRVβ types per season are shown for the hungry/high infection (blue) and harvest/low infection (maroon) seasons. The error bars represent 1SE from the mean. The Fig shows that the average numbers of peaks for virtually all 24 TCRVβ types are much lower than the 8-10 peaks seen in healthy adults. There were 26 subjects for each season of birth. Except for TCRVβ24 for which the hungry/high infection season average was significantly lower than for the harvest/low infection season average (p < 0.03), there were no significant season of birth differences in the overall number of TCRVβ peaks indicating the absence of seasonal effects on overall CD8⁺ T cell clonal diversity.