The effects of RSV on Erk, p38, JNK, Akt, and AMPK phosphorylation and total protein expressions in the renal tissues of STZ-DM rats. Equal amounts of proteins were resolved on 10% SDS-PAGE and blotted with Erk, p-Thr202/Tyr204-Erk, p38, p-Thr180/Tyr182-p38, JNK, p-Thr183/Tyr185-JNK (A), and Akt, p-Thr308-Akt, AMPK, p-Thr172-AMPK (B) antibodies. The blots were shown at the top and the quantified ratios were shown at the bottom. Results were expressed as means ± standard error (n = 5 per group). *: P < 0.05 vs. control, †: P < 0.05 vs. STZ-DM, ‡: P < 0.05 vs. DM-R0.1, CON: non-diabetic control, STZ-DM: streptozotocin-induced diabetes, DM-R0.1: DM treated with RSV (0.1 mg/kg/day) for 7 days, DM-R1: DM treated with RSV (1 mg/kg/day) for 7 days.