Figure 6

Increased association of NF-κB with Bcl-XL gene promoter in response to VPA. The association of NF-κB with Bcl-XL promoter was analyzed as described in materials and methods. (A) ChIP identifies the association of Bcl-XL promoter by NF-κB transcription factor. VPA significantly increased binding of NF-κB with Bcl-XL promoter region. (B) Densitometric quantification of ChIP assay (n = 3). Results are mean ± S.E.M. **P < 0.01 and ***P < 0.001 vs. control.