Enhanced glutamate, IP3 and cAMP activity in the cerebral cortex of Unilateral 6-hydroxydopamine induced Parkinson's rats: Effect of 5-HT, GABA and bone marrow cell supplementation

Table 1 Dopamine Content (pmol/mg protein) in the Cerebral cortex of experimental rats

Animal status	Dopamine Content (pmol/mg protein)
Control	57.05 ± 2.90
6-OHDA	3.57 ± 1.34 ^a
6-OHDA +5HT	14.21 ± 1.51 ^b,f
6-OHDA +GABA	13.38 ± 1.64 ^b,f
6-OHDA +BMC	5.24 ± 2.25 ^a
6-OHDA +5HT + BMC	37.82 ± 3.47^c,e
6-OHDA + GABA + BMC	39.63 ± 3.82 ^c,e
6-OHDA +5HT + GABA+ BMC	50.41 ± 3.02 ^c,d

Values are Mean ± S.E.M of 4-6 separate experiments. Each group consist 6-8 rats.
^a p < 0.001, ^b p < 0.01, ^c P < 0.05 when compared to Control
^d p < 0.001, ^e p < 0.01, ^f P < 0.05 when compared to 6-OHDA group.
C - Control, 6-OHDA - 6-OHDA infused, 6-OHDA +5-HT - 6-OHDA infused treated with Serotonin, 6-OHDA +GABA - 6-OHDA infused treated with GABA, 6-OHDA +BMC- 6-OHDA infused treated with BMC, 6-OHDA +5-HT+BMC- 6-OHDA infused treated with Serotonin and BMC, 6-OHDA + GABA +BMC- 6-OHDA infused treated with GABA and BMC, 6-OHDA +5-HT + GABA+ BMC- 6-OHDA infused treated with Serotonin, GABA and BMC.

ISSN: 1423-0127