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Table 3 Scatchard Analysis of NMDA receptor using [3H] MK-801 binding against MK-801 in the Cerebral cortex of Control, 6-OHDA infused, 6-OHDA+5HT, 6-OHDA+GABA and 6-OHDA+BMC treated rats

From: Enhanced glutamate, IP3 and cAMP activity in the cerebral cortex of Unilateral 6-hydroxydopamine induced Parkinson's rats: Effect of 5-HT, GABA and bone marrow cell supplementation

Animal Status

Bmax (fmoles/mg protein)

Kd (nM)

Control

261.60 ± 11.05

0.63 ± 0.11

6-OHDA

754.88 ± 16.28a

0.82 ± 0.18

6-OHDA + 5HT

619.28 ± 19.95b,f

0.75 ± 0.12

6-OHDA + GABA

638.24 ± 20.48b,f

0.77 ± 0.10

6-OHDA + BMC

669.92 ± 11.71a,f

0.80 ± 0.09

6-OHDA +5HT + BMC

328.33 ± 26.87c,e

0.72 ± 0.14

6-OHDA + GABA + BMC

344.96 ± 24.12c,e

0.65 ± 0.10

6-OHDA +5HT + GABA+ BMC

274.04 ± 15.12c,d

0.74 ± 0.08

  1. Values are Mean ± S.E.M of 4-6 separate experiments. Each group consist 6-8 rats.
  2. Bmax - Maximal binding; Kd - Dissociation constant
  3. a p < 0.001, b p < 0.01, c P < 0.05 when compared to Control,
  4. d p < 0.001, e p < 0.01, f P < 0.05 when compared to 6-OHDA group.
  5. C - Control, 6-OHDA - 6-OHDA infused, 6-OHDA +5-HT - 6-OHDA infused treated with Serotonin, 6-OHDA +GABA - 6-OHDA infused treated with GABA, 6-OHDA +BMC- 6-OHDA infused treated with BMC, 6-OHDA +5-HT+BMC- 6-OHDA infused treated with Serotonin and BMC, 6-OHDA + GABA +BMC- 6-OHDA infused treated with GABA and BMC, 6-OHDA +5-HT + GABA+ BMC- 6-OHDA infused treated with Serotonin, GABA and BMC.
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Journal of Biomedical Science

ISSN: 1423-0127