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Table 6 mGluR5 and NMDA2B expression in the Cerebral cortex of the experimental rats

From: Enhanced glutamate, IP3 and cAMP activity in the cerebral cortex of Unilateral 6-hydroxydopamine induced Parkinson's rats: Effect of 5-HT, GABA and bone marrow cell supplementation

Animal Status

Mean pixel value

 

mGluR5

NMDA2B

Control

23.25 ± 3.50

26 ± 3.1

6-OHDA

83.12 ± 3.23a

60 ± 6.1a

6-OHDA +5HT

67.12 ± 2.50b, f

50 ± 5.9b,f

6-OHDA +GABA

68.23 ± 3.05b, f

52 ± 5.7b,f

6-OHDA +BMC

79.33 ± 7.55a

59 ± 5.1a

6-OHDA +5HT + BMC

51.42 ± 5.93c,e

40 ± 5.2c,e

6-OHDA + GABA + BMC

53.77 ± 5.56c,e

42 ± 4.4c,e

6-OHDA +5HT + GABA+ BMC

35.69 ± 6.42d

30 ± 1.1d

  1. Values are Mean ± S.E.M of 4-6 separate experiments. Each group consist 6-8 rats.
  2. a p < 0.001, b p < 0.01, c P < 0.05 when compared to Control,
  3. d p < 0.001, e p < 0.01, f P < 0.05 when compared to 6-OHDA group.
  4. C - Control, 6-OHDA - 6-OHDA infused, 6-OHDA +5-HT - 6-OHDA infused treated with Serotonin, 6-OHDA +GABA - 6-OHDA infused treated with GABA, 6-OHDA +BMC- 6-OHDA infused treated with BMC, 6-OHDA +5-HT+BMC- 6-OHDA infused treated with Serotonin and BMC, 6-OHDA + GABA +BMC- 6-OHDA infused treated with GABA and BMC, 6-OHDA +5-HT + GABA+ BMC- 6-OHDA infused treated with Serotonin, GABA and BMC.