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Table 3 Univariate analysis of urothelial carcinoma risk by genotypes of GST superfamily

From: Genetic polymorphisms in glutathione S-transferase (GST) superfamily and risk of arsenic-induced urothelial carcinoma in residents of southwestern Taiwan

   Urothelial carcinoma
  No (%) Case no. HR (95% CI) P value
GSTM1     
   Non-null 312 (42.5) 18 ref  
   Null 422 (57.5) 23 0.94(0.51-1.74) 0.84
GSTT1     
   Non-null 368 (50.3) 14 ref  
   Null 363 (49.7) 27 1.91(1.00-3.65)* 0.05
GSTP1-105     
   AA 491 (64.8) 25 ref  
   AG 192 (25.3) 10 1.07(0.51-2.23) 0.86
   GG 75 (9.9) 5 1.71(0.64-4.56) 0.29
   AG+GG 267 (35.2) 15 1.21(0.64-2.31) 0.56
GSTO1-140     
   CC 521 (70.0) 27 ref  
   CA 199 (26.7) 9 0.81(0.38-1.73) 0.59
   AA 24 (3.3) 2 2.11(0.50-8.99) 0.31
   CA+AA 223 (30.0) 11 0.92(0.45-1.85) 0.80
GSTO2-(-183)     
   AA 487 (64.2) 26 ref  
   AG 234 (30.9) 11 0.73(0.36-1.48) 0.38
   GG 37 (4.9) 4 2.58(0.88-7.52) 0.08
   AG+GG 271 (35.8) 15 0.90(0.48-1.71) 0.75
GSTO2-142     
   AA 428 (56.6) 20 ref  
   AG 283 (37.4) 17 1.14(0.60-2.19) 0.69
   GG 45 (6.0) 4 2.62(0.88-7.83) 0.08
   AG+GG 328 (43.4) 21 1.28(0.69-2.37) 0.43
GSTO1(140)/O2(-183)/O2(142)   
   CAA/CAA 397 (53.8) 18 ref  
   CAA/AGG 163 (22.1) 7 0.83(0.34-1.98) 0.66
   AGG/AGG 20 (2.7) 2 3.08(0.70-13.54) 0.13
   Others 158 (21.4) 11 1.55(0.73-3.28) 0.25
  1. HR: adjusted for age/gender/cigarette smoking/education level
  2. HR: hazard ratio; CI: confidence interval
  3. * p < 0.05; **p < 0.01; ***p < 0.0001