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Table 4 Stratified analysis of urothelial carcinoma risk by genotypes of GSTM1, T1, P1, O1 and O2 according to cumulative arsenic exposure

From: Genetic polymorphisms in glutathione S-transferase (GST) superfamily and risk of arsenic-induced urothelial carcinoma in residents of southwestern Taiwan

  CAE < 20 mg/L*yr CAE 20 mg/L*yr
  No Cs No. HR (95% CI) P
value
No Cs No. HR (95% CI) P value
GSTM1         
   Non-null 165 4 ref   70 10 ref  
   Null 211 4 0.69(0.17-2.81) 0.61 110 14 0.90(0.40-2.03) 0.79
GSTT1         
   Non-null 194 6 ref   76 5 ref  
   Null 180 2 0.27(0.05-1.37) 0.11 104 19 3.25(1.20-8.80)* 0.02
GSTP1-105         
   AA 262 7 ref   112 12 ref  
   AG 93 1 0.41(0.05-3.35) 0.41 47 7 1.41(0.55-3.62) 0.47
   GG 36 0 0.00 0.99 22 4 1.76(0.51-5.73) 0.35
   AG+GG 129 1 0.33(0.04-2.66) 0.30 69 11 1.52(0.66-3.48) 0.33
GSTO1-140         
   CC 264 6 ref   126 16 ref  
   CA 106 1 0.32(0.04-2.73) 0.30 47 4 0.70(0.23-2.10) 0.52
   AA 17 0 0.00 0.99 4 2 4.79(1.03-22.39)* 0.05
   CA+AA 123 1 0.30(0.04-2.49) 0.26 51 6 0.97(0.37-2.50) 0.94
GSTO2-(-183)         
   AA 247 6 ref   115 16 ref  
   AG 119 1 0.23(0.03-2.02) 0.19 61 6 0.71(0.28-1.84) 0.48
   GG 26 1 2.04(0.23-17.88) 0.52 6 2 2.90(0.61-13.66) 0.18
   AG+GG 145 2 0.43(0.09-2.21) 0.32 67 8 0.87(0.37-2.05) 0.74
GSTO2-142         
   AA 218 4 ref   100 13 ref  
   AG 145 4 1.17(0.28-4.80) 0.83 71 8 0.88(0.37-2.14) 0.78
   GG 29 0 0.00 0.99 11 3 2.53(0.71-8.99) 0.15
   AG+GG 174 4 1.05(0.26-4.30) 0.94 82 11 1.08(0.48-2.41) 0.86
GSTO1(140)/O2(-183)/O2(142)         
   CAA/CAA 205 3 ref   94 12 ref  
   CAA/AGG 89 0 0.00 0.99 41 4 0.79(0.25-2.49) 0.69
   AGG/AGG 15 0 0.00 1.00 4 2 4.91(1.02-23.74)* 0.05
   Others 77 4 3.45(0.75-15.78) 0.11 38 4 0.85(0.27-2.65) 0.78
  1. HR adjusted for age/gender/cigarette smoking/education level * p < 0.05; **p < 0.01; ***p < 0.0001
  2. GST: glutathione S-transferase; CAE: cumulative arsenic exposure; HR: hazard ratio; CI: confidence interval;