Table 4 Stratified analysis of urothelial carcinoma risk by genotypes of GSTM1, T1, P1, O1 and O2 according to cumulative arsenic exposure

No

Cs No.

HR (95% CI)

P

value

No

Cs No.

HR (95% CI)

P value

GSTM1

   Non-null

165

4

ref

70

10

ref

   Null

211

4

0.69(0.17-2.81)

0.61

110

14

0.90(0.40-2.03)

0.79

GSTT1

   Non-null

194

6

ref

76

5

ref

   Null

180

2

0.27(0.05-1.37)

0.11

104

19

3.25(1.20-8.80)*

0.02

GSTP1-105

   AA

262

7

ref

112

12

ref

   AG

93

1

0.41(0.05-3.35)

0.41

47

7

1.41(0.55-3.62)

0.47

   GG

36

0

0.00

0.99

22

4

1.76(0.51-5.73)

0.35

   AG+GG

129

1

0.33(0.04-2.66)

0.30

69

11

1.52(0.66-3.48)

0.33

GSTO1-140

   CC

264

6

ref

126

16

ref

   CA

106

1

0.32(0.04-2.73)

0.30

47

4

0.70(0.23-2.10)

0.52

   AA

17

0

0.00

0.99

4

2

4.79(1.03-22.39)*

0.05

   CA+AA

123

1

0.30(0.04-2.49)

0.26

51

6

0.97(0.37-2.50)

0.94

GSTO2-(-183)

   AA

247

6

ref

115

16

ref

   AG

119

1

0.23(0.03-2.02)

0.19

61

6

0.71(0.28-1.84)

0.48

   GG

26

1

2.04(0.23-17.88)

0.52

6

2

2.90(0.61-13.66)

0.18

   AG+GG

145

2

0.43(0.09-2.21)

0.32

67

8

0.87(0.37-2.05)

0.74

GSTO2-142

   AA

218

4

ref

100

13

ref

   AG

145

4

1.17(0.28-4.80)

0.83

71

8

0.88(0.37-2.14)

0.78

   GG

29

0

0.00

0.99

11

3

2.53(0.71-8.99)

0.15

   AG+GG

174

4

1.05(0.26-4.30)

0.94

82

11

1.08(0.48-2.41)

0.86

GSTO1(140)/O2(-183)/O2(142)

   CAA/CAA

205

3

ref

94

12

ref

   CAA/AGG

89

0

0.00

0.99

41

4

0.79(0.25-2.49)

0.69

   AGG/AGG

15

0

0.00

1.00

4

2

4.91(1.02-23.74)*

0.05

   Others

77

4

3.45(0.75-15.78)

0.11

38

4

0.85(0.27-2.65)

0.78