Discovery of serum biomarkers of alcoholic fatty liver in a rodent model: C-reactive protein

Table 1 Levels of some clinical serum indicators in the animals

Indicators	Normal (n= 7)	AFL (n= 6)	HF-NAFL (n= 4)	HL-NAFL (n= 6)	LF^§ (n= 5)
BW (g)	270 ± 5^¶/457 ± 14^§	275 ± 3^¶	418 ± 28^§	565 ± 29^§,*	ND
AST (U/L)	154 ± 25	148 ± 34^c	164 ± 31	181 ± 63	199 ± 37*
ALT (U/L)	56 ± 15	41 ± 13^c	48 ± 17	57 ± 22	74 ± 19*
TBIL (mg/dl)	0.70 ± 0.06	0.62 ± 0.09^{a, b, c}	0.78 ± 0.04	0.75 ± 0.05	0.84 ± 0.10*
TG (mg/dl)	51 ± 16	58 ± 10^a	91 ± 14**	56 ± 11	48 ± 14
TCHO (mg/dl)	61 ± 10	68 ± 8	72 ± 10	71 ± 12	61 ± 17

BW, body weight; AST, aspartate aminotransferase; ALT, alanine aminotransferase; TBIL, total bilirulin; TG, triglyceride; TCHO, total cholesterol; AFL, alcoholic fatty liver; HF-NAFL, high fructose-induced non-alcoholic fatty liver; HL-NAFL, high lipid-induced non-alcoholic fatty liver; LF, liver fibrosis. Indicators for predicting liver function include GOT, GPT, and bilirubin and for predicting fat cells include triglyceride and cholesterol. Rats were treated before the age of 6 weeks and sacrificed by the ages of ^¶10 and ^§18 weeks. ND, Non-detection. The p value was calculated according to Student's t-test. * p < 0.05 and **p < 0.01 as compared to normal controls. A significant change (p < 0.05) was also determined for AFL rats compared to ^aHF-NAFL, ^bHL-NAFL, and ^cLF rats.

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