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Table 3 Serum concentration of C reactive protein (CRP) and haptoglobin (Hp) in clinical patients

From: Discovery of serum biomarkers of alcoholic fatty liver in a rodent model: C-reactive protein

Patients (n)

Fibrosis

(n, %)

P-steatosis

(n, %)

HAI

(n, %)

CRP

(mg/L)

Hp

(g/L)

Healthy (16)

ND

ND

ND

1.58 ± 0.48

1.13 ± 0.63

NASH (19)

F1~F2

(19, 100%)

Stage 0~1

(7, 37%)

Stage 0~4

(18, 95%)

ND

0.74 ± 0.39*

  

Stage 2~3

(12, 63%)

Stage 5~13

(1, 5%)

  

HCV-

liver fibrosis (17)

F1~F2

(7, 41%)

Stage 0~1

(15, 88%)

Stage 0~4

(2, 12%)

1.31 ± 0.44*

0.45 ± 0.58*,#

 

F3~F4

(10, 59%)

Stage 2~3

(2, 12%)

Stage 5~13

(15, 88%)

  
  1. The fibrotic stage was determined according to the Metavir classification. The stage of p-steatosis was determined according to the fatty change. HAI, necroinflammatory scores. NASH, non-alcoholic steatohepatitis; ND, not determined.* p < 0.05, compared to healthy controls. # p < 0.05, compared to NASH. The significance was calculated according to Student's t-test. The data are presented as the mean ± SEM.
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Journal of Biomedical Science

ISSN: 1423-0127