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Figure 2 | Journal of Biomedical Science

Figure 2

From: Mesenchymal stem cell transplantation ameliorates motor function deterioration of spinocerebellar ataxia by rescuing cerebellar Purkinje cells

Figure 2

Magnetic resonance images of mice after superparamagnectic iron oxide nanoparticles (SPIO)-labeled and unlabeled human mesenchymal stem cells transplantation. Mice were anesthetized, followed by injection of 8.4 × 106 per kg of mice body weight unlabeled hMSCs (A, wild-type mouse) or SPIO-labeled hMSCs (B, wide-type mouse; C, SCA2 transgenic mouse) in PBS through foramen magnum intracranially, and then measured in a 7-T MR imager 24 h later. (A) No signal was detected in the medulla or cerebellum of wild-type mouse after intracranial transplantation of unlabeled hMSCs. (B) A significant decreased T2 signal intensity of the SPIO (white arrow) was detected in the dorsal site of medulla of wild-type mouse after intracranial transplantation of SPIO-labeled hMSCs. (C) A significant decreased T2 signal intensity of the SPIO (white arrow) was detected in the dorsal site of medulla of transgenic mouse after intracranial transplantation of SPIO-labeled hMSCs. The length of each small scale was 1 mm. The letter "P" indicated posterior direction.

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