Average of rotarod performance of mouse which received intravenous human mesenchymal stem cells transplantation at sequential periods. Average of latency to fall from rotarod (in seconds) of mice after serial hMSCs implantation through intravenous injection was compared every 8 weeks. Rotarod performance of SCA2 transgenic mice (n = 14) was significantly improved at 33-40 weeks of age by serial intravenous hMSCs transplantation (*p = 0.012). The numbers of mice in Control-Wt and Control-Tg were 16 and 10, respectively. Statistical analysis between each group was performed by one-way ANOVA (p = 0.012).