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Figure 7 | Journal of Biomedical Science

Figure 7

From: Knockdown of Rab5a expression decreases cancer cell motility and invasion through integrin-mediated signaling pathway

Figure 7

Rab5a regulates the activity of Rho GTPases and reorganization of actin cytoskeleton in SiHa cells. (A) The Control and Rab5a-siRNAs cells were stained with FITC-phalloidine. Scale bars indicate 20 μm. (C) Levels of active GTP-bound Rac1, Cdc42 and GFP-RhoA in Control and Rab5a-siRNAs cells were detected by GST-pull down assays, as described in the materials and methods. Total Rac1, Cdc42 and GFP-RhoA present in the lysates were analysed by immunoblotting with their specific antibody respectively.

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Journal of Biomedical Science

ISSN: 1423-0127