Figure 1
From: Androgens as therapy for androgen receptor-positive castration-resistant prostate cancer
Progression of hormone-dependent LNCaP 104-S tumors to androgen-ablation-resistant 104-Rrel tumors, and androgenic growth suppression of 104-Rrel tumors. (A) Mice were injected subcutaneously with hormone-dependent 104-S cells. After allowing tumors to grow for 7 weeks, mice were separated into control (filled circles, 14 mice with 19 tumors) and castration groups (open circles, 24 mice with 36 tumors) and the time was designated as week 1 [18]. (B) Mice in the castrated group in (A) at the 14th week were separated into 3 groups including a control group (open circles, 6 mice with 9 tumors), a low dosage testosterone treatment group that received a subcutaneous implant of a 20 mg Testosterone/cholesterol (1:9) pellet (filled squares, 9 mice with 12 tumors), and a high-dosage testosterone treatment group that received a subcutaneous implant of a 20 mg pure Testosterone pellet (filled circles, 10 mice with 12 tumors) [18]. Tumor volumes are expressed as the mean + standard error.