Figure 3

Regression and relapse of LNCaP CDXR-3 tumor xenografts in nude mice treated with testosterone LNCaP CDXR tumor xenografts in castrated male nude mice were allowed to grow until they reached an average volume of 400 mm³ on the 38th day. All mice carrying tumors received a subcutaneous implant of a 20 mg testosterone pellet. The mice in the control group were implanted with a 20 mg testosterone pellet either at an early stage (50 days after inoculation, 7 tumors) (A) or late stage (92 days after inoculation, 7 tumors) (B) [27]. Open triangles represent tumors relapsed, while open squares represent tumors disappeared after androgen treatment. Tumor volumes are expressed as the mean ± standard error. (C) LNCaP IS-3 xenogarfts were separated into control group (20 mg cholesterol pellet implant, 9 tumors) and treatment group (20 mg testosterone pellet implant, 10 tumors) to determine the effect of androgen on growth of IS tumors [21].