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Table 1 Background and demographic characteristics of patients with Graves' disease

From: Association between copy number variation of complement component C4 and Graves' disease

Patients' characteristics Healthy (160) GD (624) Myxedema P-value GO P-value Vitiligo P-value
    No Yes   No Yes   No Yes  
Age at diagnosis            
≤ 40 145 (90.6) 307 (49.2) 247 (47.0) 59 (60.2) 0.017 182 (45.8) 125 (55.1) 0.027 239 (46.9) 68 (59.6) 0.014
> 40 15 (9.4) 317 (50.8) 278 (53.0) 39 (39.8)   215 (54.2) 102 (44.9)   271 (53.1) 46 (40.4)  
Gender            
Male 32 (20.0) 133 (21.3) 110 (21.0) 22 (22.4) 0.739 74 (18.6) 59 (26.0) 0.031 107 (21.0) 26 (22.8) 0.700
Female 128 (80.0) 491 (78.7) 415 (79.0) 76 (77.6)   323 (81.4) 168 (74.0)   403 (79.0) 88 (77.2)  
Treatment            
Radioiodine            
No   601 (96.3) 504 (96.0) 96 (98.0) 0.345 389 (98.0) 212 (93.4) 0.003 489 (95.9) 112 (98.2) 0.226
Yes   23 (3.7) 21 (4.0) 2 (2.0)   8 (2.0) 15 (6.6)   21 (4.1) 2 (1.8)  
Thyroid gland surgery            
No   564 (90.4) 472 (89.9) 91 (92.9) 0.363 363 (91.4) 201 (88.5) 0.239 457 (89.6) 107 (93.9) 0.164
Yes   60 (9.6) 53 (10.1) 7 (7.1)   34 (8.6) 26 (11.5)   53 (10.4) 7 (6.1)  
Clinical features            
Goiter            
Grade 1-3   146 (23.5) 119 (22.8) 27 (27.6) 0.309 101 (25.5) 46 (20.4) 0.154 117 (23.1) 30 (26.3) 0.462
Grade 4-5   474 (76.5) 403 (77.2) 71 (72.4)   295 (74.5) 179 (79.6)   390 (76.9) 84 (73.7)  
Nodular hyperplasia            
No   483 (77.5) 434 (82.7) 49 (50.5) 2.880 × 10-12 301 (75.8) 182 (80.5) 0.175 430 (84.3) 53 (46.9) 6.670 × 10-18
Yes   140 (22.5) 91 (17.3) 49 (49.5)   96 (24.2) 44 (19.5)   80 (15.7) 60 (53.1)  
Myxedema            
No   525 (74.3)     305 (76.8) 220 (97.3) 1.35 × 10-11 507 (99.4) 18 (15.9) 8.900 × 10-8
Yes   98 (25.7)      92 (23.2) 6 (2.7)   3 (0.6) 95 (84.1)
Graves' ophthalmopathy            
No   397 (63.6) 305 (58.0) 92 (93.9) 1.350 × 10-11     295 (57.8) 102 (89.5) 2.200 × 10-10
Yes   227 (36.4) 220 (41.9) 6 (6.1)      215 (42.2) 12 (10.5)  
Vitiligo            
No   510 (81.7) 507 (96.6) 3 (3.1) 8.900 × 10-8 295 (74.3) 215 (94.7) 2.204 × 10-10    
Yes   114 (18.3) 18 (3.4) 95 (96.9)   102 (25.7) 12 (5.3)     
  1. Abbreviations: GD, Graves, disease; GO, Graves' ophthalmopathy; SD, standard deviation; N, number.