Table 1 Background and demographic characteristics of patients with Graves' disease
From: Association between copy number variation of complement component C4 and Graves' disease
Patients' characteristics | Healthy (160) | GD (624) | Myxedema | P-value | GO | P-value | Vitiligo | P-value | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
No | Yes | No | Yes | No | Yes | ||||||
Age at diagnosis | |||||||||||
≤ 40 | 145 (90.6) | 307 (49.2) | 247 (47.0) | 59 (60.2) | 0.017 | 182 (45.8) | 125 (55.1) | 0.027 | 239 (46.9) | 68 (59.6) | 0.014 |
> 40 | 15 (9.4) | 317 (50.8) | 278 (53.0) | 39 (39.8) | 215 (54.2) | 102 (44.9) | 271 (53.1) | 46 (40.4) | |||
Gender | |||||||||||
Male | 32 (20.0) | 133 (21.3) | 110 (21.0) | 22 (22.4) | 0.739 | 74 (18.6) | 59 (26.0) | 0.031 | 107 (21.0) | 26 (22.8) | 0.700 |
Female | 128 (80.0) | 491 (78.7) | 415 (79.0) | 76 (77.6) | 323 (81.4) | 168 (74.0) | 403 (79.0) | 88 (77.2) | |||
Treatment | |||||||||||
Radioiodine | |||||||||||
No | 601 (96.3) | 504 (96.0) | 96 (98.0) | 0.345 | 389 (98.0) | 212 (93.4) | 0.003 | 489 (95.9) | 112 (98.2) | 0.226 | |
Yes | 23 (3.7) | 21 (4.0) | 2 (2.0) | 8 (2.0) | 15 (6.6) | 21 (4.1) | 2 (1.8) | ||||
Thyroid gland surgery | |||||||||||
No | 564 (90.4) | 472 (89.9) | 91 (92.9) | 0.363 | 363 (91.4) | 201 (88.5) | 0.239 | 457 (89.6) | 107 (93.9) | 0.164 | |
Yes | 60 (9.6) | 53 (10.1) | 7 (7.1) | 34 (8.6) | 26 (11.5) | 53 (10.4) | 7 (6.1) | ||||
Clinical features | |||||||||||
Goiter | |||||||||||
Grade 1-3 | 146 (23.5) | 119 (22.8) | 27 (27.6) | 0.309 | 101 (25.5) | 46 (20.4) | 0.154 | 117 (23.1) | 30 (26.3) | 0.462 | |
Grade 4-5 | 474 (76.5) | 403 (77.2) | 71 (72.4) | 295 (74.5) | 179 (79.6) | 390 (76.9) | 84 (73.7) | ||||
Nodular hyperplasia | |||||||||||
No | 483 (77.5) | 434 (82.7) | 49 (50.5) | 2.880 × 10-12 | 301 (75.8) | 182 (80.5) | 0.175 | 430 (84.3) | 53 (46.9) | 6.670 × 10-18 | |
Yes | 140 (22.5) | 91 (17.3) | 49 (49.5) | 96 (24.2) | 44 (19.5) | 80 (15.7) | 60 (53.1) | ||||
Myxedema | |||||||||||
No | 525 (74.3) | 305 (76.8) | 220 (97.3) | 1.35 × 10-11 | 507 (99.4) | 18 (15.9) | 8.900 × 10-8 | ||||
Yes | 98 (25.7) | 92 (23.2) | 6 (2.7) | 3 (0.6) | 95 (84.1) | ||||||
Graves' ophthalmopathy | |||||||||||
No | 397 (63.6) | 305 (58.0) | 92 (93.9) | 1.350 × 10-11 | 295 (57.8) | 102 (89.5) | 2.200 × 10-10 | ||||
Yes | 227 (36.4) | 220 (41.9) | 6 (6.1) | 215 (42.2) | 12 (10.5) | ||||||
Vitiligo | |||||||||||
No | 510 (81.7) | 507 (96.6) | 3 (3.1) | 8.900 × 10-8 | 295 (74.3) | 215 (94.7) | 2.204 × 10-10 | ||||
Yes | 114 (18.3) | 18 (3.4) | 95 (96.9) | 102 (25.7) | 12 (5.3) | ||||||