Table 1 Proteins, among others, that have been significantly down-regulated or up-regulated in their expression as a consequence of administration of ADNF-9 against the effect of prenatal alcohol exposure in E13 fetal brains

Heterogeneous nuclear ribonucleoprotein U-like protein (HNRL2_MOUSE)

Acts as a basic transcriptional regulator. Represses basic transcription driven by several cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro.

0.021

Dynein light chain 2, cytoplasmic (DYL2_MOUSE)

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.

0.036

Hemoglobin subunit epsilon-Y2 (HBE_MOUSE)

Hemoglobin epsilon chain is a beta-type chain found in early embryos.

0.021

Cyclin-dependent kinase inhibitor 1B (CDN1B_MOUSE)

Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Positive regulator of cyclin D-dependent kinases such as CDK4. Regulated by phosphorylation and degradation events.

0.012

Peptidyl-prolyl cis-trans isomerase FKBP4 (FKBP4_MOUSE)

Immunophilin protein with PPIase and co-chaperone activities. Component of unliganded steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly.

0.036

RNA-binding protein Raly (RALY_MOUSE)

Probable-RNA binding protein. Could be a heterogeneous nuclear ribonucleoprotein (hnRNP). May be involved in pre-mRNA splicing.

0.012

60S ribosomal protein L12 (RL12_MOUSE)

Binds directly to 26S ribosomal RNA.

2.3E-03 ± 9.60E-05

0.012

Splicing factor 3B subunit 3 (SF3B3_MOUSE)

Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential; it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing ofa rare class of nuclear pre-mRNA intron.

0.036

Peroxiredoxin-2 (PRDX2_MOUSE)

Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H₂O₂.

0.036

Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP1B_MOUSE)

Protein phosphatase (PP1) is essential for cell division; it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity.

0.036

Endoplasmin (ENPL_MOUSE)

Molecular chaperone that functions in the processing and transport of secreted proteins. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity.

0.036

Dihydropyrimidinase-related protein 1 (DPYL1_MOUSE)

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.

0.012

Serine/arginine-rich splicing factor 3 (SFRS3_MOUSE)

May be involved in RNA processing in relation with cellular proliferation and/or maturation.

7.6E-04 ± 7.33E-05

1.0E-03 ± 3.86E-05

0.036

Heat shock protein HSP 90-alpha (HS90A_MOUSE)

Molecular chaperone. Has ATPase activity

0.036

Hemoglobin subunit beta-1 (HBB1_MOUSE)

Involved in oxygen transport from the lung to the various peripheral tissues.

0.012

Transketolase (TKT_MOUSE)

Transketolase: A transferase bringing about the reversible interconversion of sedoheptulose 7-phosphate and d-glyceraldehyde 3-phosphate to produce d-ribose 5-phosphate and d-xylulose 5-phosphate, and also other similar reactions, such as hydroxypyruvate and an aldehyde into CO2 and an extended hydroxypyruvate; a part of the nonoxidative phase of the pentose phosphate pathway.

0.012

Casein kinase II subunit beta (CSK2B_MOUSE)

Plays a complex role in regulating the basal catalytic activity of the alpha subunit. Participates in Wnt signaling.

0.021

Microtubule-associated protein 1B (MAP1B_MOUSE)

The function of brain MAPS is essentially unknown. Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules.

0.036

Hemoglobin subunit zeta (HBAZ_MOUSE)

The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin, synthesized primarily in the yolk sac.

0.036

Eukaryotic translation initiation factor 5A-1 (IF5A1_MOUSE)

mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of TP53/p53 and TP53/p53-dependent apoptosis. Also regulates TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function and in skeletal muscle stem cell differentiation.

0.036

Fatty acid synthase (FAS_MOUSE)

Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.

0.036

Histone-binding protein RBBP4 (RBBP4_MOUSE)

Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes that regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair, and the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression.

0.036

Nuclear cap-binding protein subunit 1 (NCBP1_MOUSE)

Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore.

0.021