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Table 3 Candidate miR-1 targeted genes involved in apoptosis

From: MicroRNA-1 induces apoptosis by targeting prothymosin alpha in nasopharyngeal carcinoma cells

Symbol Entrez Gene Name Entrez Gene ID Fold change in NPC-TW01 Fold change in HeLa
C5 complement component 5 727 -2.96 -2.36
CARD8 caspase recruitment domain family, member 8 22900 -4.74 -2.72
FAIM Fas apoptotic inhibitory molecule 55179 -4.28 -2.54
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 2903 -2.54 -2.31
PTMA prothymosin, alpha 5757 -6.62 -2.76
TP63 tumor protein p63 (TP73L) 8626 -2.37 -2.33
  1. NPC-TW01 and HeLa cells were transfected with miR-1 and their total RNA was hybridized to microarrays. Transcripts that were down regulated more than two-fold were screened as target genes of miR-1 using the miRTarBas and miRecord databases. The target genes were then screened for involvement in apoptosis using the Ingenuity pathways database.