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Figure 2 | Journal of Biomedical Science

Figure 2

From: Methamphetamine-induced changes in the striatal dopamine pathway in μ-opioid receptor knockout mice

Figure 2

Binding of dopamine D1 ligand [3H]SCH23390 in the brains of METH-sensitized wild-type and μ-OR knockout mice. Binding of dopamine D1 ligand [3H]SCH23390 in the brains of METH-sensitized wild-type and μ-OR knockout mice. Both strains of mice were pretreated with daily injections saline or METH (10 mg/kg) for 7 consecutive days. Mice were killed 4 days after the final injection and brain tissues were taken for autoradiographic analysis of [3H]SCH23390 binding. Representative autoradiograms of [3H]SCH23390 binding are shown on the top. Mean values ± SEM are presented. Numbers in parentheses represent the number of animals/brains studied. * indicates a significant difference (P < 0.05) from METH-sensitized wild-type mice; # indicates a significant difference (P < 0.05) from saline-treated μ-OR knockout mice.

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