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Figure 3 | Journal of Biomedical Science

Figure 3

From: Hesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio

Figure 3

Inhibition of PDE4-induced cAMP hydrolysis by HDME (A) and Ro 20-1724 (B). Activities of PDE4 in the presence of various concentrations of HDME or Ro 20-1724, and the substrate (cAMP) were plotted according to a Lineweaver-Burk analysis. Ki was determined from the equation of the apparent Km as a function of the inhibitor concentration (inset). Each value represents the mean ± SEM (n = 3).

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