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Figure 7 | Journal of Biomedical Science

Figure 7

From: Hesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio

Figure 7

Effects of HDME (3~30 μmol/kg, p.o.) on total IgG 2a and IgE. Effects of HDME (3~30 μmol/kg, p.o.) on total IgG2a (A), total IgE (B) and ovalbumin-specific IgE (C) levels in the serum and bronchial alveolar lavage fluid (D, E) of sensitized mice which had received aerosolized methacholine (6.25~50 mg/ml) 2 days after primary allergen challenge. # p < 0.05, ## p < 0.01 and ### p < 0.001, compared to the non-challenged group. * p < 0.05, ** p < 0.01 and *** p < 0.001, compared to the control (vehicle) group. Each value represents the mean ± SEM. The number of mice in each group was 10.

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