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Figure 4 | Journal of Biomedical Science

Figure 4

From: Excessive Dpp signaling induces cardial apoptosis through dTAK1 and dJNK during late embryogenesis of Drosophila

Figure 4

Dpp signalings was affected in raw mutants. (A, C) The expression of dpp-LacZ was normal in both wild-type and raw mutants at stage 13. (B, D) At stage 14, dpp-LacZ was expressed in the leading edge of wild-type embryos whereas dpp-LacZ was ectopically expressed in dorsal ectoderm of raw mutant embryos. (E, G) At stage 13, pMad was detected at the dorsal ectoderm in both wild-type (WT) and raw mutants. (F, H) Expression of pMad in epidermis was reduced in the wild-type embryos but was greatly increased in raw mutant embryos at stage 14 (brackets). (I, K) Optical section through the stained embryos revealed that the broad-band expression pattern of pMad was persisted in the dorsal mesoderm of raw mutant embryos but not in wild-type embryos. (J, L) At stage 16 pMad was detected in developing midgut and hindgut in wild-type embryos. Its expression in raw mutant embryos was mostly abolished. WT, wild-type; st, stage.

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