Figure 8
JNK induced cardiac apoptosis is p53 dependent. (A, B) Constitutive overexpression of p35 or dominant negative p53DN, using Act5C-gal4 driver, antagonized dpp-induced apoptosis. (C, D) Mesodermal expression of p35 or p53DN suppressed dTAK1- induced apoptosis. (E, F) Overexpressed p35 or p53DN driven by 24B-gal4 suppressed apoptosis in raw mutants. (G) Loss of raw function resulted in loss of heart cells as revealed by anti-Tin antibodies in control 24B-gal4 driver. (H) Excessive Tin-positive heart cells were present when p53DN was expressed in raw mutants (arrow).